PURB

Across TCGA pan-cancer cohorts, PURB Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PURB data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher PURB Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PURB expression acts as an unfavorable survival marker.

ESCA, BLCA, and UCEC are the cancer types where PURB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	All	0.080	0.533	<.001	18	view →
BLCA	DFS	Median	All	0.363	0.629	.025	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	DFS	Median	All	0.213	0.676	.012	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PURB–ESCA (DFS)

Open the ESCA breakdown →