PURB

Across TCGA pan-cancer cohorts, PURB mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PURB data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PURB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PURB expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

UCEC, GBM, and HNSC are the cancer types where PURB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.494	1.000	.016	28	view →
GBM	OS	Quartile	All	0.453	0.214	.023	2	view →
HNSC	DFS	Median	III,IV	0.524	0.715	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PURB–UCEC (OS)

Open the UCEC breakdown →