PURB

Across TCGA patient cohorts, PURB mutation is significantly associated with the RNA expression of many other genes, with 3,056 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PURB-associated genes across cancer lineages are RNA5SP516, RNU6ATAC30P, and LINC00363. Each is linked with PURB in more than 1 cancer types. Because this analysis shows association rather than direction, both PURB-to-partner and partner-to-PURB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP516 grouped by PURB-low versus PURB-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PURB→partner) and Y-score (partner→PURB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP516 →	+0.217	+5.455	<.001	.001	3	2
UCEC	RNU6ATAC30P →	+0.261	+1.751	.001	.003	3	2
UCEC	LINC00363 →	+0.090	+2.504	.004	.006	3	2
UCEC	RNA5SP420 →	+0.388	+1.719	.001	.006	3	2
BLCA	RPS10P21 →	+0.197	+3.680	<.001	.009	3	2
UCEC	YTHDF3-AS1 →	+0.676	+2.439	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,056 associations by consensus.

RNA5SP516 by PURB expression — BLCA

Explore this box plot interactively →