PURB

Across TCGA patient cohorts, PURB mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PURB-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and A-Raf_pS299. Each is linked with PURB in more than 1 cancer types. Because this analysis shows association rather than direction, both PURB-to-partner and partner-to-PURB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PURB-low versus PURB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PURB→partner) and Y-score (partner→PURB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.127	-2.673	.001	.005	3	1
UCEC	EGFR_pY1068 →	-0.320	-2.087	<.001	.005	3	1
UCEC	A-Raf_pS299 →	-0.143	-2.321	.001	.033	3	1
UCEC	ERK2 →	+0.220	+1.678	.002	.023	3	1
UCEC	FOXO3a_pS318_S321 →	-0.118	-2.212	.013	.010	3	1
UCEC	GAPDH →	+0.559	+2.700	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

14-3-3_beta by PURB expression — UCEC

Explore this box plot interactively →