PURB

Across TCGA cell cohorts, PURB RNA expression is significantly associated with the go_rna of many other GO terms, with 4,661 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PURB-associated GO terms across cancer lineages are Regulation of translational initiation, 2-oxoglutarate decarboxylation to succinyl-CoA, and Negative regulation of myoblast fusion. Each is linked with PURB in more than 15 cancer types. Because this analysis shows association rather than direction, both PURB-to-partner and partner-to-PURB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translational initiation grouped by PURB-low versus PURB-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PURB→partner) and Y-score (partner→PURB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of translational initiation →	+0.105	+0.783	<.001	<.001	3	16
OESOPHAGUS	2-oxoglutarate decarboxylation to succinyl-CoA →	+0.154	+1.052	.002	<.001	2	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.145	+0.822	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.138	+0.714	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Protein polyubiquitination →	+0.054	+0.742	<.001	<.001	3	15
KIDNEY	Regulation of mRNA stability →	+0.048	+0.905	.005	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,661 associations by consensus.

Regulation of translational initiation by PURB expression — OVARY

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