PURB

Across TCGA cell cohorts, PURB mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PURB-associated genes across cancer lineages are TRIM49D1, SMIM28, and MOG. Each is linked with PURB in more than 1 cancer types. Because this analysis shows association rather than direction, both PURB-to-partner and partner-to-PURB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM49D1 grouped by PURB-low versus PURB-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PURB→partner) and Y-score (partner→PURB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TRIM49D1 →	+0.104	+4.870	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	SMIM28 →	+0.288	+4.870	<.001	.001	3	1
LARGE_INTESTINE	MOG →	+0.085	+2.791	.004	.005	3	1
LARGE_INTESTINE	NUTM2E →	+0.276	+3.304	.004	.005	3	1
LARGE_INTESTINE	FAM205A →	+0.014	+3.029	.006	.003	2	1
LARGE_INTESTINE	TRPC5 →	+0.012	+2.716	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TRIM49D1 by PURB expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →