PUM1

Across TCGA pan-cancer cohorts, PUM1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PUM1 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PUM1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PUM1 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, LUAD, and GBM are the cancer types where PUM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	1.000	0.888	.014	42	view →
LUAD	OS	Tertile	III,IV	0.829	0.394	.011	32	view →
GBM	DFS	Median	All	0.334	0.202	.018	11	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	9	view →
UCEC	DFS	Median	All	1.000	0.936	.023	4	view →
LSCC	DFS	Median	II,III,IV	0.485	1.000	.006	4	view →
CCRCC	OS	Median	All	0.783	0.895	.038	3	view →
HNSC	DFS	Median	III,IV	0.538	0.738	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PUM1–COAD (DFS)

Open the COAD breakdown →