PUM1

Across TCGA patient cohorts, PUM1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,254 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PUM1-associated genes across cancer lineages are LYPLA2, CDC20, and KHDRBS1. Each is linked with PUM1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PUM1-to-partner and partner-to-PUM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PUM1 versus LYPLA2 in OV, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUM1→partner) and Y-score (partner→PUM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LYPLA2 →	+0.627	+0.195	<.001	.002	3	6
UCEC	CDC20 →	+1.877	+0.255	<.001	<.001	3	6
UCEC	KHDRBS1 →	+0.499	+0.203	<.001	<.001	3	6
BRCA	AUNIP →	+0.778	+0.181	<.001	<.001	3	6
UCEC	GNL2 →	+0.560	+0.223	<.001	<.001	3	6
OV	RBBP4 →	+0.475	+0.177	.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,254 associations by consensus.

PUM1 vs LYPLA2 — OV

Explore this scatter interactively →