PUM1

Across TCGA patient cohorts, PUM1 mutation is significantly associated with the RNA expression of many other genes, with 3,477 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUM1-associated genes across cancer lineages are RBBP8, AAGAB, and CRTAM. Each is linked with PUM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PUM1-to-partner and partner-to-PUM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBBP8 grouped by PUM1-low versus PUM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUM1→partner) and Y-score (partner→PUM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RBBP8 →	+0.690	+2.099	<.001	<.001	3	3
UCEC	AAGAB →	+0.379	+1.900	<.001	<.001	3	3
UCEC	CRTAM →	+0.327	+1.443	.002	.003	3	3
UCEC	EIF2B2 →	+0.307	+1.915	.001	.001	3	3
UCEC	NIP7 →	+0.445	+1.879	<.001	<.001	3	3
UCEC	CXCL9 →	+2.073	+2.099	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,477 associations by consensus.

RBBP8 by PUM1 expression — UCEC

Explore this box plot interactively →