PUM1

Across TCGA patient cohorts, PUM1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUM1-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and mTOR_pS2448. Each is linked with PUM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PUM1-to-partner and partner-to-PUM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PUM1-low versus PUM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUM1→partner) and Y-score (partner→PUM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.709	+1.522	<.001	.017	3	4
UCEC	eIF4E →	+0.194	+1.938	.005	.001	3	2
UCEC	mTOR_pS2448 →	-0.109	-1.794	.026	.024	3	2
UCEC	Notch1 →	+0.137	+1.687	.003	.013	3	2
UCEC	ASNS →	+0.292	+1.415	.014	.043	3	2
UCEC	ATM →	-0.326	-1.794	.029	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Caspase-7-cleavedD198 by PUM1 expression — UCEC

Explore this box plot interactively →