PUM1

Across TCGA cell cohorts, PUM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,975 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PUM1-associated GO terms across cancer lineages are Regulation of DNA-templated transcription initiation, Epigenetic regulation of gene expression, and Regulation of transcription initiation by RNA polymerase II. Each is linked with PUM1 in more than 17 cancer types. Because this analysis shows association rather than direction, both PUM1-to-partner and partner-to-PUM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated transcription initiation grouped by PUM1-low versus PUM1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PUM1→partner) and Y-score (partner→PUM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of DNA-templated transcription initiation →	+0.066	+0.635	<.001	<.001	3	18
BONE	Epigenetic regulation of gene expression →	+0.092	+0.970	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Regulation of transcription initiation by RNA polymerase II →	+0.062	+0.855	<.001	<.001	3	18
BONE	Heterochromatin formation →	+0.077	+0.987	.004	<.001	2	18
BONE	Negative regulation of gene expression, epigenetic →	+0.085	+1.034	.001	<.001	3	17
BONE	Nucleic acid transport →	+0.134	+1.019	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,975 associations by consensus.

Regulation of DNA-templated transcription initiation by PUM1 expression — LUNG_SCLC

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