PUM1

Across TCGA cell cohorts, PUM1 mutation is significantly associated with the RNA expression of many other genes, with 784 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PUM1-associated genes across cancer lineages are RBMXL2, CCDC13, and FTMT. Each is linked with PUM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PUM1-to-partner and partner-to-PUM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMXL2 grouped by PUM1-low versus PUM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUM1→partner) and Y-score (partner→PUM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RBMXL2 →	+0.063	+2.647	<.001	.001	3	2
LARGE_INTESTINE	CCDC13 →	+0.346	+3.364	<.001	.002	3	2
SOFT_TISSUE	FTMT →	+0.086	+5.977	<.001	.001	3	1
KIDNEY	ZNF728 →	+0.013	+5.000	<.001	.005	3	1
LARGE_INTESTINE	ANKRD54 →	+0.548	+3.451	.001	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.772	+3.451	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 784 associations by consensus.

RBMXL2 by PUM1 expression — LARGE_INTESTINE

Explore this box plot interactively →