PUF60

Across TCGA pan-cancer cohorts, PUF60 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PUF60’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where PUF60 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PUF60 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LSCC, COAD, and LUAD are the cancer types where PUF60 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PUF60 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+0.488	<.001	9	view →
COAD	Male	III,IV	+0.454	<.001	9	view →
LUAD	Female	All	+0.342	<.001	9	view →
HNSC	Male	IV	+0.200	<.001	8	view →
PDAC	Female	II,III,IV	−0.239	<.001	3	view →
CCRCC	All	All	+0.052	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PUF60–LSCC

Open the LSCC breakdown →