PUF60

Across TCGA patient cohorts, PUF60 mutation is significantly associated with the RNA expression of many other genes, with 474 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUF60-associated genes across cancer lineages are MIR4766, TRAJ57, and RNA5SP492. Each is linked with PUF60 in more than 1 cancer types. Because this analysis shows association rather than direction, both PUF60-to-partner and partner-to-PUF60 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4766 grouped by PUF60-low versus PUF60-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUF60→partner) and Y-score (partner→PUF60) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4766 →	+0.464	+1.865	.001	.009	3	2
SKCM	TRAJ57 →	+0.777	+5.362	<.001	.005	3	2
SKCM	RNA5SP492 →	+0.365	+5.037	<.001	.009	3	2
SKCM	RNA5SP468 →	+0.433	+4.979	<.001	.009	3	2
CESC	MYCLP1 →	+0.042	+4.934	.002	.002	3	1
CESC	RNA5SP198 →	+0.305	+5.144	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 474 associations by consensus.

MIR4766 by PUF60 expression — UCEC

Explore this box plot interactively →