PUF60

Across TCGA patient cohorts, PUF60 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUF60-associated genes across cancer lineages are XBP1, ATM, and 14-3-3_beta. Each is linked with PUF60 in more than 1 cancer types. Because this analysis shows association rather than direction, both PUF60-to-partner and partner-to-PUF60 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XBP1 grouped by PUF60-low versus PUF60-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUF60→partner) and Y-score (partner→PUF60) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XBP1 →	-0.173	-3.169	.015	.019	3	1
UCEC	ATM →	-0.543	-3.000	.017	.036	3	1
UCEC	14-3-3_beta →	-0.128	-3.446	.011	.005	2	1
UCEC	Notch1 →	+0.163	+3.009	.020	.019	2	1
UCEC	Di-Ras3 →	-0.160	-2.321	.031	.035	2	1
UCEC	Fibronectin →	-0.376	-2.321	.023	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

XBP1 by PUF60 expression — UCEC

Explore this box plot interactively →