PUDP

Across TCGA pan-cancer cohorts, PUDP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PUDP data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PUDP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PUDP expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and CCRCC are the cancer types where PUDP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.889	.023	24	view →
PDAC	OS	Median	III,IV	0.892	0.309	<.001	20	view →
CCRCC	DFS	Median	II,III,IV	0.887	0.283	.012	17	view →
LUAD	OS	Tertile	III,IV	0.534	0.995	.013	9	view →
HNSC	OS	Median	IV	0.931	1.000	.048	1	view →
LSCC	DFS	Median	III,IV	1.000	0.867	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PUDP–COAD (DFS)

Open the COAD breakdown →