PUDP

Across TCGA patient cohorts, PUDP mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUDP-associated genes across cancer lineages are Shc_pY317, c-Jun_pS73, and 14-3-3_beta. Each is linked with PUDP in more than 1 cancer types. Because this analysis shows association rather than direction, both PUDP-to-partner and partner-to-PUDP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by PUDP-low versus PUDP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUDP→partner) and Y-score (partner→PUDP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.172	-2.584	.006	.010	3	2
UCEC	c-Jun_pS73 →	-0.177	-3.446	.006	.005	3	2
UCEC	14-3-3_beta →	-0.085	-3.143	.039	.018	3	1
UCEC	EGFR_pY1068 →	-0.274	-3.000	.008	.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.116	-2.105	.024	.017	3	1
UCEC	FOXO3a →	-0.089	-1.794	.034	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Shc_pY317 by PUDP expression — UCEC

Explore this box plot interactively →