PTX4

Across TCGA patient cohorts, PTX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,100 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PTX4-associated GO terms across cancer lineages are Positive regulation of canonical Wnt signaling pathway, Obsolete histone modification, and Nuclear-transcribed mRNA poly(A) tail shortening. Each is linked with PTX4 in more than 21 cancer types. Because this analysis shows association rather than direction, both PTX4-to-partner and partner-to-PTX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of canonical Wnt signaling pathway grouped by PTX4-low versus PTX4-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTX4→partner) and Y-score (partner→PTX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Positive regulation of canonical Wnt signaling pathway →	+0.059	+0.207	<.001	<.001	3	22
SCLC	Obsolete histone modification →	+0.106	+0.236	<.001	<.001	3	21
STAD	Nuclear-transcribed mRNA poly(A) tail shortening →	+0.068	+0.185	<.001	<.001	3	21
DLBC	Maintenance of cell number →	+0.067	+0.294	.001	.009	2	21
STAD	Regulation of canonical Wnt signaling pathway →	+0.054	+0.197	<.001	<.001	3	20
SCLC	Obsolete histone methylation →	+0.124	+0.139	<.001	.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,100 associations by consensus.

Positive regulation of canonical Wnt signaling pathway by PTX4 expression — STAD

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