PTX4

Across TCGA patient cohorts, PTX4 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTX4-associated genes across cancer lineages are ERK2, Fibronectin, and Annexin-1. Each is linked with PTX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTX4-to-partner and partner-to-PTX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PTX4-low versus PTX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTX4→partner) and Y-score (partner→PTX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.264	+3.169	.012	.020	3	1
UCEC	Fibronectin →	-0.451	-3.169	.012	.020	3	1
UCEC	Annexin-1 →	+0.788	+3.169	.006	.020	3	1
UCEC	4E-BP1 →	+0.508	+2.837	<.001	.035	3	1
SKCM	Lck →	-0.396	-2.000	.008	.031	3	1
SKCM	MYH11 →	-0.813	-3.169	.035	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ERK2 by PTX4 expression — UCEC

Explore this box plot interactively →