PTX4

Across TCGA cell cohorts, PTX4 mutation is significantly associated with the RNA expression of many other genes, with 283 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTX4-associated genes across cancer lineages are GALP, F11, and TSPY4. Each is linked with PTX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTX4-to-partner and partner-to-PTX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALP grouped by PTX4-low versus PTX4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTX4→partner) and Y-score (partner→PTX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GALP →	+2.038	+4.981	<.001	.008	3	2
LARGE_INTESTINE	F11 →	+0.028	+2.619	.004	.002	3	2
PANCREAS	TSPY4 →	+0.050	+5.614	<.001	.002	3	1
PANCREAS	OR10G9 →	+0.030	+5.614	<.001	.002	3	1
BLOOD_Leukemia	GZMK →	+0.456	+3.359	<.001	.002	3	1
BLOOD_Leukemia	HHLA1 →	+0.007	+3.381	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 283 associations by consensus.

GALP by PTX4 expression — CNS

Explore this box plot interactively →