PTS

Across TCGA patient cohorts, PTS mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTS-associated genes across cancer lineages are MIR5194, ATP5MGP6, and RNU6-1312P. Each is linked with PTS in more than 1 cancer types. Because this analysis shows association rather than direction, both PTS-to-partner and partner-to-PTS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5194 grouped by PTS-low versus PTS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTS→partner) and Y-score (partner→PTS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR5194 →	+0.645	+4.648	.003	.001	3	1
UCEC	ATP5MGP6 →	+0.465	+4.003	.001	.005	3	1
LUSC	RNU6-1312P →	+0.261	+7.924	<.001	.008	3	1
LUSC	RNU6-508P →	+0.269	+7.924	.001	.008	3	1
LUSC	RNU4-17P →	+0.208	+7.924	<.001	.008	3	1
LUSC	MIR329-1 →	+0.205	+7.924	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MIR5194 by PTS expression — UCEC

Explore this box plot interactively →