PTS

Across TCGA cell cohorts, PTS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,092 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTS-associated GO terms across cancer lineages are Negative regulation of chromosome segregation, Spindle checkpoint signaling, and Negative regulation of nuclear division. Each is linked with PTS in more than 10 cancer types. Because this analysis shows association rather than direction, both PTS-to-partner and partner-to-PTS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome segregation grouped by PTS-low versus PTS-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTS→partner) and Y-score (partner→PTS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of chromosome segregation →	+0.103	+0.809	.001	.002	3	11
KIDNEY	Spindle checkpoint signaling →	+0.092	+0.727	.001	<.001	3	11
LUNG_SCLC	Negative regulation of nuclear division →	+0.101	+0.700	.002	.004	2	11
OESOPHAGUS	Platelet activating factor catabolic process →	+0.295	+1.251	<.001	<.001	3	10
KIDNEY	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.116	+0.809	.001	.002	3	10
KIDNEY	Negative regulation of chromosome separation →	+0.116	+0.809	.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,092 associations by consensus.

Negative regulation of chromosome segregation by PTS expression — KIDNEY

Explore this box plot interactively →