Across TCGA patient cohorts, PTRH1 mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTRH1-associated genes across cancer lineages are MIR1266, MIR4727, and MIR6821. Each is linked with PTRH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTRH1-to-partner and partner-to-PTRH1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTRH1→partner) and Y-score (partner→PTRH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR1266 →	+0.429	+4.771	<.001	.006	3	2
UCEC	MIR4727 →	+0.690	+4.551	<.001	.009	3	1
UCEC	MIR6821 →	+0.853	+4.552	<.001	.005	3	1
CESC	RN7SL65P →	+0.166	+5.010	<.001	.009	3	1
CESC	RNU6-927P →	+0.441	+5.103	<.001	.008	3	1
CESC	RNU6-1089P →	+0.456	+5.103	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Exploration

PTRH1 survival (RNA) · tumor vs normal (RNA) · all PTRH1 data types