PTPRZ1

Across TCGA pan-cancer cohorts, PTPRZ1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PTPRZ1 data layer compared with 25 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PTPRZ1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PTPRZ1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where PTPRZ1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	1.000	0.401	<.001	34	view →
LUAD	DFS	Quartile	All	0.839	0.998	.004	10	view →
HNSC	DFS	Quartile	All	0.792	0.534	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PTPRZ1–LSCC (DFS)

Open the LSCC breakdown →