Across TCGA patient cohorts, PTPRT mutation is significantly associated with the RNA expression of many other genes, with 10,552 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PTPRT-associated genes across cancer lineages are WDHD1, GNPNAT1, and ACBD5. Each is linked with PTPRT in more than 6 cancer types. Because this analysis shows association rather than direction, both PTPRT-to-partner and partner-to-PTPRT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRT→partner) and Y-score (partner→PTPRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDHD1 →	+0.510	+1.577	<.001	<.001	3	7
UCEC	GNPNAT1 →	+0.440	+1.419	<.001	<.001	3	6
STAD	ACBD5 →	+0.611	+2.919	<.001	<.001	3	6
STAD	P4HA1 →	+0.707	+2.321	<.001	<.001	3	6
SKCM	DLGAP5 →	+0.579	+0.864	<.001	<.001	3	6
UCEC	PARP2 →	+0.361	+1.444	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,552 associations by consensus.

Exploration

PTPRT survival (RNA) · tumor vs normal (RNA) · all PTPRT data types