Across TCGA patient cohorts, PTPRT mutation is significantly associated with the total protein of many other genes, with 107 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRT-associated genes across cancer lineages are PCNA, Cyclin-E2, and ATM. Each is linked with PTPRT in more than 4 cancer types. Because this analysis shows association rather than direction, both PTPRT-to-partner and partner-to-PTPRT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRT→partner) and Y-score (partner→PTPRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PCNA →	+0.207	+3.459	.027	.004	3	5
UCEC	Cyclin-E2 →	+0.144	+1.270	<.001	.001	3	5
UCEC	ATM →	-0.427	-1.986	<.001	<.001	3	5
UCEC	4E-BP1 →	+0.293	+1.392	<.001	<.001	3	5
LUAD	ASNS →	+0.516	+2.321	<.001	.004	3	4
UCEC	Cyclin-B1 →	+0.649	+1.519	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

Exploration

PTPRT survival (RNA) · tumor vs normal (RNA) · all PTPRT data types