Across TCGA cell cohorts, PTPRT mutation is significantly associated with the RNA expression of many other genes, with 898 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRT-associated genes across cancer lineages are MC4R, NSMCE3, and OR52I2. Each is linked with PTPRT in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPRT-to-partner and partner-to-PTPRT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRT→partner) and Y-score (partner→PTPRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MC4R →	+0.193	+3.409	<.001	.005	3	3
SKIN	NSMCE3 →	+0.349	+2.115	.003	.004	3	3
SOFT_TISSUE	OR52I2 →	+0.016	+4.635	<.001	.003	3	2
BLOOD_Myeloma	TEX13A →	+0.292	+3.906	.004	.009	3	2
BREAST	TAAR9 →	+0.012	+4.196	<.001	.006	3	2
BLOOD_Leukemia	VSIR →	-1.752	-2.555	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 898 associations by consensus.

Exploration

PTPRT survival (RNA) · tumor vs normal (RNA) · all PTPRT data types