PTPRN

Across TCGA patient cohorts, PTPRN mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRN-associated genes across cancer lineages are p27_pT198, 4E-BP1, and Cyclin-B1. Each is linked with PTPRN in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPRN-to-partner and partner-to-PTPRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by PTPRN-low versus PTPRN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRN→partner) and Y-score (partner→PTPRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.071	+1.502	.032	.027	3	3
UCEC	4E-BP1 →	+0.284	+2.444	<.001	.001	3	3
UCEC	Cyclin-B1 →	+0.536	+1.643	.002	.003	3	3
LUSC	14-3-3_beta →	-0.122	-2.990	.043	.036	3	2
LUSC	ACVRL1 →	-0.173	-2.972	.034	.036	3	2
LUSC	p62 Lck ligand →	+1.059	+3.009	<.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

p27_pT198 by PTPRN expression — UCEC

Explore this box plot interactively →