PTPRM

Across TCGA pan-cancer cohorts, PTPRM Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated PTPRM data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PTPRM Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated PTPRM expression acts as an unfavorable survival marker, although some lineages such as UCEC and READ show a favorable association.

UCEC, READ, and ESCA are the cancer types where PTPRM Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.920	0.293	.001	34	view →
READ	DFS	Median	II,III,IV	1.000	0.442	.010	13	view →
ESCA	OS	Median	III,IV	0.108	0.574	<.001	12	view →
SCLC	OS	Median	III,IV	0.082	0.639	<.001	12	view →
COAD	OS	Median	II,III,IV	0.690	0.859	.009	9	view →
LGG	OS	Median	All	0.341	0.801	.005	6	view →
GBM	OS	Median	All	0.079	0.415	.003	6	view →
SARC	OS	Median	All	0.210	0.745	.014	6	view →
BLCA	OS	Median	IV	0.183	0.608	<.001	6	view →
SKCM	DFS	Median	II,III,IV	1.000	0.682	.028	4	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

PTPRM–UCEC (DFS)

Open the UCEC breakdown →