PTPRM

Across TCGA patient cohorts, PTPRM protein abundance is significantly associated with the RNA expression of many other genes, with 16,369 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PTPRM-associated genes across cancer lineages are ITGA10, VWF, and CENPA. Each is linked with PTPRM in more than 6 cancer types. Because this analysis shows association rather than direction, both PTPRM-to-partner and partner-to-PTPRM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPRM versus ITGA10 in BRCA, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRM→partner) and Y-score (partner→PTPRM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ITGA10 →	+0.776	+0.375	<.001	<.001	3	6
OV	VWF →	+1.060	+0.311	.001	.009	3	5
LUAD	CENPA →	-1.212	-0.333	<.001	<.001	3	5
LUAD	ACADL →	+1.298	+0.256	<.001	<.001	3	5
CCRCC	AOX1 →	+1.410	+0.321	.001	.001	3	5
BRCA	RBMS3 →	+0.688	+0.353	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,369 associations by consensus.

PTPRM vs ITGA10 — BRCA

Explore this scatter interactively →