PTPRM

Across TCGA patient cohorts, PTPRM mutation is significantly associated with the total protein of many other genes, with 93 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRM-associated genes across cancer lineages are ATM, Cyclin-B1, and TFRC. Each is linked with PTPRM in more than 5 cancer types. Because this analysis shows association rather than direction, both PTPRM-to-partner and partner-to-PTPRM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PTPRM-low versus PTPRM-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRM→partner) and Y-score (partner→PTPRM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.656	-2.906	<.001	.001	3	6
UCEC	Cyclin-B1 →	+0.624	+1.847	<.001	<.001	3	5
STAD	TFRC →	+0.672	+2.736	.001	<.001	3	4
COAD	Caspase-7-cleavedD198 →	+1.270	+2.807	<.001	.003	3	4
COAD	PCNA →	+0.236	+1.686	.005	.013	3	4
STAD	Caveolin-1 →	-0.760	-2.906	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

ATM by PTPRM expression — COAD

Explore this box plot interactively →