PTPRM

Across TCGA cell cohorts, PTPRM RNA expression is significantly associated with the go_rna of many other GO terms, with 5,550 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PTPRM-associated GO terms across cancer lineages are Negative regulation of proteolysis, Macroautophagy, and Biological process involved in interaction with host. Each is linked with PTPRM in more than 11 cancer types. Because this analysis shows association rather than direction, both PTPRM-to-partner and partner-to-PTPRM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of proteolysis grouped by PTPRM-low versus PTPRM-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRM→partner) and Y-score (partner→PTPRM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of proteolysis →	+0.163	+3.432	<.001	<.001	3	12
STOMACH	Macroautophagy →	+0.065	+1.941	.007	.001	2	11
BONE	Biological process involved in interaction with host →	+0.123	+4.098	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of protein K48-linked ubiquitination →	+0.188	+2.008	<.001	.001	3	10
BONE	Positive regulation of cell-substrate adhesion →	+0.136	+3.014	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Viral process →	+0.076	+1.683	<.001	.006	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,550 associations by consensus.

Negative regulation of proteolysis by PTPRM expression — BONE

Explore this box plot interactively →