PTPRK

Across TCGA pan-cancer cohorts, PTPRK mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PTPRK data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PTPRK mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PTPRK expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, CCRCC, and COAD are the cancer types where PTPRK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	1.000	0.830	.007	10	view →
CCRCC	OS	Quartile	II,III,IV	0.930	0.610	.011	9	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.905	.045	6	view →
PDAC	DFS	Median	All	0.861	0.590	.006	6	view →
LUAD	OS	Quartile	III,IV	0.848	0.357	.011	6	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	2	view →
GBM	DFS	Tertile	All	0.262	0.464	.044	2	view →
LSCC	DFS	Tertile	All	0.643	0.838	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PTPRK–UCEC (OS)

Open the UCEC breakdown →