PTPRK

Across TCGA patient cohorts, PTPRK protein abundance is significantly associated with the RNA expression of many other genes, with 8,093 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PTPRK-associated genes across cancer lineages are PTPRK-AS1, FRK, and HEBP2. Each is linked with PTPRK in more than 6 cancer types. Because this analysis shows association rather than direction, both PTPRK-to-partner and partner-to-PTPRK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPRK versus PTPRK-AS1 in LUAD, with a Pearson correlation of 0.66.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRK→partner) and Y-score (partner→PTPRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PTPRK-AS1 →	+0.658	+0.433	<.001	<.001	3	7
LSCC	FRK →	+0.883	+0.337	<.001	.001	3	5
BRCA	HEBP2 →	+0.574	+0.475	<.001	<.001	3	5
LUAD	TRIM2 →	+0.868	+0.394	.004	.005	3	4
CCRCC	FBXL5 →	+0.428	+0.333	.002	<.001	3	4
GBM	REPS2 →	+1.117	+0.274	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,093 associations by consensus.

PTPRK vs PTPRK-AS1 — LUAD

Explore this scatter interactively →