PTPRK

Across TCGA patient cohorts, PTPRK mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRK-associated genes across cancer lineages are Caspase-7-cleavedD198, p27_pT198, and eIF4E. Each is linked with PTPRK in more than 5 cancer types. Because this analysis shows association rather than direction, both PTPRK-to-partner and partner-to-PTPRK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PTPRK-low versus PTPRK-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRK→partner) and Y-score (partner→PTPRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.526	+2.815	<.001	.001	3	6
LUAD	p27_pT198 →	+0.125	+2.321	.049	.035	3	3
UCEC	eIF4E →	+0.130	+1.691	.020	.011	3	3
UCEC	MEK1 →	+0.286	+2.247	.003	.001	3	3
UCEC	PCNA →	+0.197	+2.321	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.230	+1.681	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Caspase-7-cleavedD198 by PTPRK expression — COAD

Explore this box plot interactively →