PTPRK

Across TCGA cell cohorts, PTPRK mutation is significantly associated with the RNA expression of many other genes, with 905 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRK-associated genes across cancer lineages are C16orf72, HTD2, and BCLAF1. Each is linked with PTPRK in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPRK-to-partner and partner-to-PTPRK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf72 grouped by PTPRK-low versus PTPRK-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRK→partner) and Y-score (partner→PTPRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	C16orf72 →	+0.700	+3.070	<.001	.008	3	2
CNS	HTD2 →	+0.505	+3.238	.001	.006	3	2
CNS	BCLAF1 →	+0.470	+3.067	.001	.009	3	2
BLOOD_Leukemia	R3HDML →	+0.008	+3.762	<.001	.007	3	2
LUNG_SCLC	ACTL9 →	+0.409	+3.584	.002	.003	3	2
LARGE_INTESTINE	TFIP11 →	+0.395	+3.459	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 905 associations by consensus.

C16orf72 by PTPRK expression — CNS

Explore this box plot interactively →