Across TCGA pan-cancer cohorts, PTPRK-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated PTPRK-AS1 data layer.
The strongest signal is observed in mesothelioma (MESO), where higher PTPRK-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PTPRK-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and BRCA show a favorable association.
MESO, UVM, and ACC are the cancer types where PTPRK-AS1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.