PTPRJ

Across TCGA patient cohorts, PTPRJ mutation is significantly associated with the RNA expression of many other genes, with 2,668 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRJ-associated genes across cancer lineages are KLHL3, RBM18, and ATP1B2. Each is linked with PTPRJ in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPRJ-to-partner and partner-to-PTPRJ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL3 grouped by PTPRJ-low versus PTPRJ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRJ→partner) and Y-score (partner→PTPRJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KLHL3 →	-0.471	-1.447	<.001	.003	3	4
UCEC	RBM18 →	+0.372	+1.771	<.001	<.001	3	3
SKCM	ATP1B2 →	-1.447	-2.496	.004	.002	3	3
LUSC	PSAT1P4 →	+0.101	+2.656	.005	.002	3	3
LUSC	MSANTD3 →	+0.631	+3.357	.001	.005	3	3
UCEC	GCH1 →	+0.498	+1.479	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,668 associations by consensus.

KLHL3 by PTPRJ expression — UCEC

Explore this box plot interactively →