PTPRJ

Across TCGA patient cohorts, PTPRJ mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRJ-associated genes across cancer lineages are SF2, p38-MAPK_pT180_Y182, and ATM. Each is linked with PTPRJ in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPRJ-to-partner and partner-to-PTPRJ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SF2 grouped by PTPRJ-low versus PTPRJ-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRJ→partner) and Y-score (partner→PTPRJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SF2 →	+0.368	+3.021	.042	.018	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.323	-2.584	.045	.011	3	2
SKCM	ATM →	-0.490	-3.000	.007	.035	2	3
UCEC	eIF4E →	+0.199	+1.807	.001	<.001	3	2
UCEC	INPP4B →	-0.261	-2.247	.006	.001	3	2
UCEC	Notch1 →	+0.172	+1.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

SF2 by PTPRJ expression — STAD

Explore this box plot interactively →