PTPRG

Across TCGA pan-cancer cohorts, PTPRG mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PTPRG data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PTPRG mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PTPRG expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LSCC, LUAD, and GBM are the cancer types where PTPRG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.936	1.000	.010	26	view →
LUAD	OS	Quartile	All	0.894	0.603	.003	19	view →
GBM	OS	Quartile	All	0.644	0.321	<.001	16	view →
PDAC	OS	Tertile	All	0.596	0.416	.021	11	view →
CCRCC	OS	Tertile	All	1.000	0.566	.018	7	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PTPRG–LSCC (OS)

Open the LSCC breakdown →