PTPRG

Across TCGA patient cohorts, PTPRG mutation is significantly associated with the RNA expression of many other genes, with 6,379 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRG-associated genes across cancer lineages are NDUFA8, EIF2B2, and EIF2S1. Each is linked with PTPRG in more than 4 cancer types. Because this analysis shows association rather than direction, both PTPRG-to-partner and partner-to-PTPRG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA8 grouped by PTPRG-low versus PTPRG-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRG→partner) and Y-score (partner→PTPRG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	NDUFA8 →	+0.349	+2.618	.007	.005	3	4
STAD	EIF2B2 →	+0.458	+3.472	.001	.002	3	4
UCEC	EIF2S1 →	+0.589	+1.689	<.001	<.001	3	4
STAD	PSMD6 →	+0.332	+2.618	.002	.005	3	4
STAD	APEH →	+0.453	+3.346	.009	.004	3	4
UCEC	LSM3 →	+0.493	+2.137	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,379 associations by consensus.

NDUFA8 by PTPRG expression — STAD

Explore this box plot interactively →