PTPRG

Across TCGA patient cohorts, PTPRG mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRG-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and ATM. Each is linked with PTPRG in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPRG-to-partner and partner-to-PTPRG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PTPRG-low versus PTPRG-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRG→partner) and Y-score (partner→PTPRG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eIF4E →	+0.213	+3.021	.006	.017	3	4
COAD	Caspase-7-cleavedD198 →	+0.921	+2.459	.005	.018	3	4
UCEC	ATM →	-0.582	-2.280	<.001	<.001	3	4
SKCM	GAPDH →	+0.565	+3.169	.031	.017	3	3
UCEC	MEK1 →	+0.310	+1.632	.002	<.001	3	3
COAD	PKC-b-II_pS660 →	-0.411	-2.321	.005	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

eIF4E by PTPRG expression — STAD

Explore this box plot interactively →