PTPRG

Across TCGA cell cohorts, PTPRG RNA expression is significantly associated with the go_rna of many other GO terms, with 4,017 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PTPRG-associated GO terms across cancer lineages are Adiponectin-activated signaling pathway, Positive regulation of pinocytosis, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with PTPRG in more than 11 cancer types. Because this analysis shows association rather than direction, both PTPRG-to-partner and partner-to-PTPRG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Adiponectin-activated signaling pathway grouped by PTPRG-low versus PTPRG-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRG→partner) and Y-score (partner→PTPRG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Adiponectin-activated signaling pathway →	+0.099	+1.541	.008	.009	3	12
LUNG_NSCLC_LUSC	Positive regulation of pinocytosis →	+0.135	+2.195	<.001	<.001	3	11
KIDNEY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.085	+1.123	.001	<.001	3	9
BLOOD_Leukemia	Hair follicle placode formation →	+0.039	+1.522	<.001	<.001	3	9
BLOOD_Lymphoma	Nucleocytoplasmic transport →	+0.047	+1.103	.008	.001	2	10
BLOOD_Lymphoma	Response to oscillatory fluid shear stress →	+0.107	+1.329	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,017 associations by consensus.

Adiponectin-activated signaling pathway by PTPRG expression — BONE

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