PTPRG

Across TCGA cell cohorts, PTPRG mutation is significantly associated with the RNA expression of many other genes, with 544 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRG-associated genes across cancer lineages are CCDC70, R3HDML, and FBXW10. Each is linked with PTPRG in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPRG-to-partner and partner-to-PTPRG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC70 grouped by PTPRG-low versus PTPRG-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRG→partner) and Y-score (partner→PTPRG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CCDC70 →	+0.235	+3.280	<.001	.004	3	2
BLOOD_Leukemia	R3HDML →	+0.010	+3.984	<.001	.006	3	2
LARGE_INTESTINE	FBXW10 →	+0.170	+2.215	.001	.003	3	2
LARGE_INTESTINE	LYG1 →	+0.891	+3.850	<.001	<.001	3	2
LARGE_INTESTINE	FAM124A →	+0.697	+2.032	<.001	.009	3	2
LARGE_INTESTINE	IQCC →	+0.444	+2.129	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 544 associations by consensus.

CCDC70 by PTPRG expression — STOMACH

Explore this box plot interactively →