PTPRE

Across TCGA patient cohorts, PTPRE mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRE-associated genes across cancer lineages are Akt, ATM, and Bad_pS112. Each is linked with PTPRE in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPRE-to-partner and partner-to-PTPRE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt grouped by PTPRE-low versus PTPRE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRE→partner) and Y-score (partner→PTPRE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt →	-0.140	-1.574	.035	.008	3	3
UCEC	ATM →	-0.629	-1.906	<.001	<.001	3	3
UCEC	Bad_pS112 →	-0.116	-1.571	.032	.032	3	3
UCEC	JNK_pT183_Y185 →	-0.152	-2.247	.001	.001	3	2
LUSC	DJ-1 →	+0.243	+3.009	.005	.019	3	2
UCEC	EGFR_pY1068 →	-0.213	-1.152	.003	.048	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Akt by PTPRE expression — UCEC

Explore this box plot interactively →