PTPRE

Across TCGA cell cohorts, PTPRE mutation is significantly associated with the RNA expression of many other genes, with 184 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRE-associated genes across cancer lineages are PRR23A, EDDM3B, and MIOX. Each is linked with PTPRE in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPRE-to-partner and partner-to-PTPRE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR23A grouped by PTPRE-low versus PTPRE-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRE→partner) and Y-score (partner→PTPRE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRR23A →	+0.039	+4.371	<.001	.005	3	2
PANCREAS	EDDM3B →	+0.015	+4.614	<.001	.004	3	1
LARGE_INTESTINE	MIOX →	+0.309	+3.212	<.001	.006	3	1
LARGE_INTESTINE	ATP13A1 →	+0.484	+3.299	.007	.004	3	1
LARGE_INTESTINE	RNF19B →	+0.755	+3.299	.006	.004	3	1
LARGE_INTESTINE	NDUFAF4 →	+0.610	+3.212	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 184 associations by consensus.

PRR23A by PTPRE expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →