PTPRD

Across TCGA patient cohorts, PTPRD mutation is significantly associated with the RNA expression of many other genes, with 8,240 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRD-associated genes across cancer lineages are TYMS, NUDT5, and NDC80. Each is linked with PTPRD in more than 5 cancer types. Because this analysis shows association rather than direction, both PTPRD-to-partner and partner-to-PTPRD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYMS grouped by PTPRD-low versus PTPRD-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRD→partner) and Y-score (partner→PTPRD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TYMS →	+0.949	+4.169	<.001	<.001	3	6
LUAD	NUDT5 →	+0.245	+1.045	<.001	.003	3	6
COAD	NDC80 →	+0.770	+3.820	<.001	<.001	3	5
UCEC	CDKN3 →	+0.566	+1.306	<.001	<.001	3	5
SKCM	DYNC2I2 →	+0.319	+1.260	<.001	.001	3	5
HNSC	RITA1 →	+0.388	+3.530	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,240 associations by consensus.

TYMS by PTPRD expression — COAD

Explore this box plot interactively →