PTPRD

Across TCGA patient cohorts, PTPRD mutation is significantly associated with the total protein of many other genes, with 84 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRD-associated genes across cancer lineages are cIAP, TFRC, and TIGAR. Each is linked with PTPRD in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPRD-to-partner and partner-to-PTPRD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, cIAP grouped by PTPRD-low versus PTPRD-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRD→partner) and Y-score (partner→PTPRD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	cIAP →	+0.111	+3.000	.033	.027	3	4
UCEC	TFRC →	+0.331	+1.106	.007	.017	3	4
BLCA	TIGAR →	+0.128	+1.824	.025	.015	3	3
COAD	ATM →	-0.570	-3.459	<.001	.004	3	3
LUAD	EGFR_pY1068 →	-0.253	-1.678	.034	.018	3	3
LUAD	4E-BP1_pS65 →	+0.099	+1.652	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

cIAP by PTPRD expression — ESCA

Explore this box plot interactively →