PTPRD

Across TCGA cell cohorts, PTPRD RNA expression is significantly associated with the go_rna of many other GO terms, with 3,447 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTPRD-associated GO terms across cancer lineages are Positive regulation of organelle assembly, Positive regulation of double-strand break repair, and Intracellular calcium ion homeostasis. Each is linked with PTPRD in more than 8 cancer types. Because this analysis shows association rather than direction, both PTPRD-to-partner and partner-to-PTPRD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of organelle assembly grouped by PTPRD-low versus PTPRD-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRD→partner) and Y-score (partner→PTPRD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of organelle assembly →	+0.057	+0.669	.002	.005	3	9
LUNG_SCLC	Positive regulation of double-strand break repair →	+0.083	+1.953	<.001	.001	3	9
LUNG_SCLC	Intracellular calcium ion homeostasis →	-0.080	-1.750	.002	.002	3	9
BLOOD_Leukemia	ATP biosynthetic process →	+0.055	+1.144	<.001	.001	3	9
SOFT_TISSUE	Protein localization to nucleus →	+0.057	+3.351	<.001	<.001	3	8
SOFT_TISSUE	Regulation of RNA stability →	+0.070	+3.139	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,447 associations by consensus.

Positive regulation of organelle assembly by PTPRD expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →