PTPRD

Across TCGA cell cohorts, PTPRD mutation is significantly associated with the RNA expression of many other genes, with 1,208 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRD-associated genes across cancer lineages are IRGQ, PATE1, and RXFP2. Each is linked with PTPRD in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPRD-to-partner and partner-to-PTPRD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRGQ grouped by PTPRD-low versus PTPRD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRD→partner) and Y-score (partner→PTPRD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IRGQ →	+0.384	+3.584	.001	<.001	3	3
BLOOD_Myeloma	PATE1 →	+0.036	+3.906	.001	.001	3	2
OESOPHAGUS	RXFP2 →	+0.008	+2.857	.004	.007	3	2
OESOPHAGUS	TMEM196 →	+0.041	+2.847	.001	.004	3	2
OESOPHAGUS	CTXN3 →	+0.113	+3.754	<.001	<.001	3	2
KIDNEY	PRB4 →	+0.038	+4.121	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,208 associations by consensus.

IRGQ by PTPRD expression — LARGE_INTESTINE

Explore this box plot interactively →